Lithium Hydroxide → HCID 67467360, 화합물
반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([F:14])[CH:8]=[C:9]2[S:13][CH:12]=[N:11][C:10]=12)=[O:4].[OH-].[Li+]>O1CCCC1>[F:14][C:7]1[CH:8]=[C:9]2[S:13][CH:12]=[N:11][C:10]2=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=1참가 물질
4
실험 절차
To a solution of 6-fluoro-benzothiazole-4-carboxylic acid methyl ester (1.97 g, 9.33 mmol) in tetrahydrofuran (30 mL) was added aqueous lithium hydroxide solution (2M, 14.0 mL, 28 mmol, 3 eq.) and then stirred, at room temperature, for 4 hr. The reaction mixture was quenched with aqueous hydrochloric acid (2M, 30 mL) and stirred for 15 min. The resulting suspension was filtered and the solid produced was washed with water and air dried to give the title compound as a grey solid (1.51 g, 82%).
후처리
- customThe reaction mixture was quenched with aqueous hydrochloric acid (2M, 30 mL)
- stirringstirred for 15 min
- filtrationThe resulting suspension was filtered
- customthe solid produced
- washwas washed with water and air
- customdried
출처 및 근거
- ORD 기록
- ord-4bf6b7af6c3740719a1f51777b9d8357
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08916593B2
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