4-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile → 4-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzylamine

HRID 1406330노트

반응식

HRID 1406330 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=2[F:15])=[C:4]([F:18])[CH:3]=1>N.[Ni]>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([CH2:11][NH2:12])=[CH:9][C:8]=2[F:15])=[C:4]([F:18])[CH:3]=1

참가 물질

4

반응물 1

HCID 667894214-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile

생성물 1

HCID 584879074-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzylamine수율 99%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 222Ammonia용매

실험 절차

1.0 g (3.76 mmol) of 4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile were hydrogenated in 30 mL methanolic ammonia solution with the addition of Raney nickel at 50° C. under a hydrogen pressure of 50 psi. Then the catalyst was filtered off and the filtrate was evaporated to dryness. The crude product thus obtained was reacted further without any further purification.

후처리

  1. filtrationThen the catalyst was filtered off
  2. customthe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-e937f86b4fdf4fd49a4a5821587aecaa
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916589B2

반응 노트

불러오는 중…