Ammonia → 1-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamine

HRID 1406333노트

반응식

HRID 1406333 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[N:15]O)[CH3:14])=[CH:9][CH:8]=2)=[C:4]([F:19])[CH:3]=1.N.[H][H]>CO.[Ni]>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([CH:13]([NH2:15])[CH3:14])=[CH:11][CH:12]=2)=[C:4]([F:19])[CH:3]=1

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 866588121-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethanone-oximeHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 584879121-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamine수율 89%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

2.60 g (9.3 mmol) of 1-[4-(4-chloro-2-fluoro-phenoxy)-phenyl]-ethanone-oxime were dissolved in 20 mL methanol, then combined with 30 mL 7N methanolic ammonia solution and after the addition of 0.2 g Raney nickel hydrogenated at ambient temperature and 50 psi hydrogen pressure. Then the catalyst was filtered off and the filtrate was evaporated down. The crude product thus obtained was reacted further without any further purification.

후처리

  1. customhydrogenated at ambient temperature
  2. filtrationThen the catalyst was filtered off
  3. customthe filtrate was evaporated down

출처 및 근거

ORD 기록
ord-3d8902e9953a4ddfa68ff2712a45a7f9
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916589B2

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