Ammonia → HCID 43189234, 화합물

HRID 1406342

반응식

HRID 1406342 반응식
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[H][H].[NH3:21]>[Ni]>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([NH2:21])[CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 27772531-(4-(4-Methoxyphenoxy)phenyl)ethan-1-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 43189234HCID 43189234, 화합물

시약·촉매·용매 1

HCID 935Nickel촉매2회

반응 조건

온도
50 °C

실험 절차

78 mg (0.32 mmol) of 1-[4-(4-methoxy-phenoxy)-phenyl]-ethanone were dissolved in 10 ml of 7M methanolic ammonia and combined with 50 mg of Raney nickel. The mixture was shaken for 6 h at 50° C. and 3 bar hydrogen pressure. Raney nickel was added twice more and hydrogenation was continued for 2 h and 6 h under the same conditions. The catalyst was removed by suction filtering and the residue was evaporated down.

후처리

  1. waithydrogenation was continued for 2 h and 6 h under the same conditions
  2. customThe catalyst was removed by suction
  3. filtrationfiltering
  4. customthe residue was evaporated down

출처 및 근거

ORD 기록
ord-e1c080c3ddbd4ac1939198ac2b945bd3
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916589B2

연결된 노트

불러오는 중…