Sodium borohydride → 4-(4-Bromo-2-chloro-phenoxy)-benzylamine

HRID 1406360노트

반응식

HRID 1406360 반응식
[Br:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([CH:11]=[N:12]O)=[CH:9][CH:8]=2)=[C:4]([Cl:18])[CH:3]=1.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[Br:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([CH2:11][NH2:12])=[CH:9][CH:8]=2)=[C:4]([Cl:18])[CH:3]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 866588184-(4-Bromo-2-chloro-phenoxy)-benzaldehyde-oxime

생성물 1

HCID 289663904-(4-Bromo-2-chloro-phenoxy)-benzylamine

시약·촉매·용매 2

HCID 11791229Dichloronickel;hexahydrate촉매HCID 887Methanol용매

실험 절차

18 mg (0.06 mmol) of 4-(4-bromo-2-chloro-phenoxy)-benzaldehyde-oxime was dissolved in 2 mL methanol, then 37 mg (0.15 mmol) of nickel(II)chloride hexahydrate and 21 mg (0.56 mmol) of sodium borohydride were slowly added. The reaction mixture was stirred overnight at RT and then purified by chromatography (reversed phase).

후처리

  1. custompurified by chromatography (reversed phase)

출처 및 근거

ORD 기록
ord-3ccc45aa815c4eaa9de64efc9b27ebdf
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916589B2

반응 노트

불러오는 중…