N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl)butyramide hydrochloride → HCID 25012250, 화합물
반응식
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1>Cl>[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1참가 물질
3
실험 절차
The purified solid was taken up in HCl (4M in 1,4 dioxane, 30 mL) and stirred at RT for 4.5 h. The volatiles were removed in vacuo and the residue was triturated with Et2O to give N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy)quinazolin-2-yl)phenyl)butyramide hydrochloride (0.091 g, 0.171 mmol, 55% over two steps). MS 497 (M+1). HPLC retention time 5.547 mins.
후처리
- customThe volatiles were removed in vacuo
- customthe residue was triturated with Et2O