Hexane → methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate

HRID 14077

반응식

HRID 14077 반응식
[CH2:1]([O:8][CH2:9][CH2:10][C@@H:11]([C:20]([OH:22])=[O:21])[NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][Si](C=[N+]=[N-])(C)C.CCCCCC>CO.C1C=CC=CC=1>[CH2:1]([O:8][CH2:9][CH2:10][C@@H:11]([C:20]([O:22][CH3:23])=[O:21])[NH:12][C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 167693TrimethylsilyldiazomethaneHCID 15058464O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine

생성물 1

HCID 54564501methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate

시약·촉매·용매 1

HCID 21927730Benzene methanol용매

실험 절차

To O-benzyl-N-(tert-butoxycarbonyl)homoserine (5.8 g, 18.9 mmol) in 20% methanol/benzene (72 mL) is added 2M trimethylsilyldiazomethane in hexane (12.3 mL, 24.5 mmol), and the reaction stirred at room temperature 1.5 h. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 324.2 [M+H]+.

후처리

  1. concentrationThe solution is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-92306b3288f94584930245ab3ab8e0d5
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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