Hydrochloric Acid → 3-Isopropylbenzylamine Hydrochloride

HRID 14083

반응식

HRID 14083 반응식
[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8])([CH3:3])=[CH2:2].[ClH:12]>C(O)C.C(O)(=O)C.CO.C(OCC)C.[Pd]>[ClH:12].[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8])([CH3:3])[CH3:2]

참가 물질

8

반응물 2

HCID 313Hydrochloric AcidHCID 121802503-Isopropenylbenzonitrile

생성물 1

HCID 210858343-Isopropylbenzylamine Hydrochloride

시약·촉매·용매 5

HCID 23938Palladium촉매HCID 176Acetic Acid용매HCID 702Ethanol용매HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

A solution of 3-isopropenylbenzonitrile (6.0 g, 41.9 mmol) and 10% Pd/C (600 mg) in ethanol (65 mL) and acetic acid (2.4 mL) is degassed with nitrogen for 15 min, and shaken under an atmosphere of hydrogen at 50 psi for 12 h. The reaction mixture is filtered through diatomaceous earth and concentrated under reduced pressure to provide an oil. The oil is dissolved in methanol (5 mL) and hydrochloric acid (15 mL of a 1 M solution in diethyl ether) is added. The resulting precipitate is collected by filtration to provide the title compound. APCI MS m/z 149 [M+H]+.

후처리

  1. filtrationThe reaction mixture is filtered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure
  3. customto provide an oil
  4. filtrationThe resulting precipitate is collected by filtration

출처 및 근거

ORD 기록
ord-0e40f910a0c8435fa67987e268e28a55
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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