Hydrochloric Acid → Hydrochloric Acid

HRID 1408377노트

반응식

HRID 1408377 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]2[S:15][CH:16]=[C:17]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH:31]=[N:30][N:29]=[N:28]4)=[CH:23][CH:22]=3)[N:18]=2)[CH2:9]1)=O)(C)(C)C.[ClH:32]>ClCCl.CO.O1CCOCC1>[N:27]1([C:24]2[CH:23]=[CH:22][C:21]([O:20][CH2:19][C:17]3[N:18]=[C:14]([CH:10]4[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]4)[S:15][CH:16]=3)=[CH:26][CH:25]=2)[CH:31]=[N:30][N:29]=[N:28]1.[ClH:32]

참가 물질

7

반응물 2

HCID 313Hydrochloric AcidHCID 57986828HCID 57986828, 화합물

생성물 2

HCID 313Hydrochloric AcidHCID 57473380HCID 57473380, 화합물

시약·촉매·용매 3

HCID 887Methanol용매HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

A solution of 3-[4-(4-Tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 1.13 mmol) in dichloromethane (10 mL) and methanol (2 mL) were treated with 2 mL of 4N HCl in dioxane. The resulting solution was stirred at room temperature for 30 minutes. The solvents were removed in vacuo to afford the desired product as an HCl salt.

후처리

  1. customThe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-e3e3d89e29d040edba0f97bce62238d8
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921350B2

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