Acetic Anhydride → N-[(5-bromo-2-chlorophenyl)methyl]acetamide

HRID 1408415노트

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HRID 1408415 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:10])=[C:6]([CH2:8][NH2:9])[CH:7]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:10])=[C:6]([CH2:8][NH:9][C:11](=[O:13])[CH3:12])[CH:7]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 43378979(5-Bromo-2-chlorophenyl)methanamine2회

생성물 1

HCID 67151142N-[(5-bromo-2-chlorophenyl)methyl]acetamide

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
100 °C

실험 절차

To a solution of 5-bromo-2-chlorobenzenemethanamine (i.e. the product of Step A) (600 mg, 2.72 mmol) in toluene (10 mL) at 0° C. was added acetic anhydride (0.55 mL, 5.45 mmol). The reaction mixture was stirred at 100° C. for 3 h. The reaction mixture was then extracted with ethyl acetate (3×), and the organic layers were combined, washed with water and brine and dried (Na2SO4). The solvent was evaporated to provide the title product (600 mg).

후처리

  1. extractionThe reaction mixture was then extracted with ethyl acetate (3×)
  2. washwashed with water and brine
  3. dry with materialdried (Na2SO4)
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-5664014ba3a342219a3482f8bc3cb41a
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921360B2

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