Sulfuric Acid → HCID 178509482, 화합물
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[CH:11][NH:10][N:9]=2)=[CH:4][C:3]=1[CH2:13][NH:14]C(=O)C.S(=O)(=O)(O)O.[OH-].[Na+]>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[CH:11][NH:10][N:9]=2)=[CH:4][C:3]=1[CH2:13][NH2:14]참가 물질
5
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of N-[[2-chloro-5-(1H-pyrazol-3-yl)phenyl]methyl]acetamide (i.e. the product of Step B) (2.0 g, 8.0 mmol), sulfuric acid (1.5 mL) and water (7.0 mL) was heated to 120° C. for 15 h. The reaction mixture was then cooled to ambient temperature, basified with 10% NaOH solution and extracted with ethyl acetate. The combined extracts were washed with brine, dried (Na2SO4) and concentrated to yield the title product as a solid (1.0 g), which was used in the next step without further purification.
후처리
- temperatureThe reaction mixture was then cooled to ambient temperature
- extractionextracted with ethyl acetate
- washThe combined extracts were washed with brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-88e817d6c89a4443b4b9f54c670eb770
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08921360B2
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