Hydrochloric Acid → 1015474-47-1

HRID 1409633노트

반응식

HRID 1409633 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[C:11](=[O:28])[N:12]([CH:20]1[CH2:25][CH2:24][C:23](=[O:26])[NH:22][C:21]1=[O:27])[C:13]([CH3:19])=[N:14]2)(C)(C)C.[ClH:30]>CO.C(Cl)Cl.CCOCC>[ClH:30].[NH2:7][CH2:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[C:11](=[O:28])[N:12]([CH:20]1[CH2:25][CH2:24][C:23](=[O:26])[NH:22][C:21]1=[O:27])[C:13]([CH3:19])=[N:14]2

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 24968304HCID 24968304, 화합물

생성물 1

HCID 249683051015474-47-1

시약·촉매·용매 3

HCID 887Methanol용매HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

To a stirred brown solution of [3-(2,6-dioxo-piperidin-3-yl)-2-methyl-4-oxo-3,4-dihydro-quinazolin-5-ylmethyl]-carbamic acid tert-butyl ester (10.4 g, 25.9 mmol) in methanol (108 mL) and methylene chloride (108 mL), was added 2 M HCl in ether (304 mL), and the mixture was stirred overnight. Solvent was evaporated, and the residue was stirred in ether (200 mL) for 2 hours. The suspension was filtered to give 3-(5-aminomethyl-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione hydrogen chloride as a light yellow solid (8.9 g, 102% crude yield). The product was used in the next step without further purification.

후처리

  1. customSolvent was evaporated
  2. stirringthe residue was stirred in ether (200 mL) for 2 hours
  3. filtrationThe suspension was filtered

출처 및 근거

ORD 기록
ord-2a28673f9ab44886a30fe14abcd3595e
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921385B2

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