Hydrochloric Acid → HCID 178478713, 화합물

HRID 1409861노트

반응식

HRID 1409861 반응식
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH:17]2[C:22]2[CH:23]=[C:24]3[CH:28]=[CH:27][CH:26]=[C:25]3[O:29][CH:30]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:32].C(OCC)C>ClCCl>[ClH:32].[ClH:32].[O:29]1[C:25]2=[CH:26][CH:27]=[CH:28][C:24]2=[CH:23][C:22]([CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][N:16]2[CH2:15][CH2:14][C@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)=[CH:30]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178453896HCID 178453896, 화합물

생성물 1

HCID 178478713HCID 178478713, 화합물수율 88%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of trans-{4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester (2.3 g, 5.39 mmol) in dichloromethane (40 ml) was added at room temperature hydrochloric acid solution (4M in dioxane, 20.2 ml, 80.9 mmol) and the mixture was allowed to stir for 2 h, diethyl ether (50 ml) was added and the mixture was allowed to stir for 30 min at room temperature. The precipitate was collected by filtration, washed with diethyl ether and dried to yield the title compound as a white solid (1.89 g, 88%), MS (ISP) m/z=327.4 [(M+H)−], mp 339° C.

후처리

  1. stirringto stir for 30 min at room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with diethyl ether
  4. customdried

출처 및 근거

ORD 기록
ord-8e1e814fe8644ea5ab77d55806ebeef6
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921397B2

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