Sodium Hydroxide → 2-(2,2-Difluoroethoxy)-4-(methylamino)-5-nitrobenzoic acid
반응식
[F:1][CH:2]([F:21])[CH2:3][O:4][C:5]1[CH:15]=[C:14]([NH:16][CH3:17])[C:13]([N+:18]([O-:20])=[O:19])=[CH:12][C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>O1CCOCC1>[F:1][CH:2]([F:21])[CH2:3][O:4][C:5]1[CH:15]=[C:14]([NH:16][CH3:17])[C:13]([N+:18]([O-:20])=[O:19])=[CH:12][C:6]=1[C:7]([OH:9])=[O:8]참가 물질
4
실험 절차
The sub-title compound was prepared in accordance with Example 72, step (b) using ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate ((950 mg; 3.12 mmol) see Example 59, step (f)), NaOH (3.1 mL; 2 M aq; 6.2 mmol) and 1,4-dioxane (10 mL). Yield: 800 mg (93%).
출처 및 근거
- ORD 기록
- ord-66e8947105c54bb6ab876d0daf357552
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08921405B2
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