Diisopropylethylamine → 2-(2-((6-Chlorohexyl)oxy)ethoxy)ethanamine

HRID 1411227노트

반응식

HRID 1411227 반응식
FC(F)(F)C([O-])=O.[Cl:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][NH3+:21].C(N(C(C)C)CC)(C)C>CN(C=O)C>[Cl:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][NH2:21]

참가 물질

4

반응물 2

HCID 81531DiisopropylethylamineHCID 866717092-[2-(6-Chlorohexyloxy)ethoxy]ethylammonium trifluoroacetate

생성물 1

HCID 100884642-(2-((6-Chlorohexyl)oxy)ethoxy)ethanamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To one equivalent of the succinimidyl ester of the reporter group in DMF is added 3 equivalence of 2-[2-(6-chlorohexyloxy)-ethoxy]-ethyl-ammonium trifluoro-acetate stock solution, followed by diisopropylethylamine. The reaction is stirred from 8 to 16 hours at room temperature. Purification is accomplished by preparative scale HPLC or silica gel chromatography.

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-de7eff52ebdc4c42bd477c7d79400eff
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921620B2

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