Water → HCID 54477182, 화합물

HRID 1413083노트

반응식

HRID 1413083 반응식
[OH:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8].O.[C:10](OC(=O)C)(=[O:12])[CH3:11]>N1C=CC=CC=1>[C:10]([O:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8])(=[O:12])[CH3:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 5289581(S)-3-hydroxypiperidin-2-one

생성물 1

HCID 54477182HCID 54477182, 화합물수율 89%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 460 mg of (S)-(-)-3-hydroxy-2-piperidone [A. Hunter, Biochemical Journal, 35, 1298 (1941); mp. 170°-171° C., [α]D26 =-3.0°±0.1° (c=7.027, H2O)] in 6 ml of pyridine is added 2 ml of acetic anhydride, and the mixture is allowed to stand at room temperature overnight and concentrated under reduced pressure. The residue is crystallized from ether and then recrystallized from ether to give 560 mg of (S)-(-)-3-acetoxy-2-piperidone as pillar crystals in 89% yield.

후처리

  1. concentrationconcentrated under reduced pressure
  2. customThe residue is crystallized from ether
  3. customrecrystallized from ether

출처 및 근거

ORD 기록
ord-324b8e8ecaf7488990ccbd34135f998e
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04248865

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