2-Aminomethyl-1-ethylpyrrolidine → HCID 20293650, 화합물

HRID 1413146

반응식

HRID 1413146 반응식
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH2:9])[CH3:2].[CH2:10]([S:12]([C:15]1[CH:16]=[C:17]([C:25](Cl)=[O:26])[C:18]2[O:23][CH2:22][CH2:21][O:20][C:19]=2[CH:24]=1)(=[O:14])=[O:13])[CH3:11]>>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:25]([C:17]1[C:18]2[O:23][CH2:22][CH2:21][O:20][C:19]=2[CH:24]=[C:15]([S:12]([CH2:10][CH3:11])(=[O:14])=[O:13])[CH:16]=1)=[O:26])[CH3:2]

참가 물질

3

반응물 2

HCID 1172952-Aminomethyl-1-ethylpyrrolidineHCID 205447287-Ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride

생성물 1

HCID 20293650HCID 20293650, 화합물수율 69.8%

실험 절차

In a similar manner 64.5 g of dextrorotary-1-ethyl-2-aminomethylpyrrolidine was reacted with 146 g of 7-ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride to give, after treatment and purification, 133.5 g of dextrorotatory N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide (M.P.: 111°-112° C.; yield: 69.8%); (α)D20 =55.5° (in 5% solution in dimethylformamide).

후처리

  1. customto give

출처 및 근거

ORD 기록
ord-4ea498dbfb854b9fa9e5efd4ea6e8bce
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04248885

연결된 노트

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