Acetic Anhydride → 8-Acetamido-1,4-benzodioxan-5-carboxylic acid
반응식
[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>C(O)(=O)C>[NH:1]([C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1)[C:15]([CH3:16])=[O:17]참가 물질
4
실험 절차
43 g of 8-amino-1,4-benzodioxane-5-carboxylic acid and 72 ml of acetic acid were introduced into a balloon flask and then 24.5 ml of acetic anhydride were added in portions. The mixture was heated to 60°-70° C. and then cooled. The precipitate was dried off, washed with acetic acid and water and dried. 44 g of 8-acetamino-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 233° C.; yield: 84%).
후처리
- temperatureThe mixture was heated to 60°-70° C.
- temperaturecooled
- customThe precipitate was dried off
- washwashed with acetic acid and water
- customdried
출처 및 근거
- ORD 기록
- ord-3fc86df0dcfe4f6b9f5a023155cd9ca6
- 출처 데이터셋
- uspto-grants-1981_02
- 특허 번호
- US04248885
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