5-Fluorouracil → 1,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione

HRID 1413197

반응식

HRID 1413197 반응식
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[O:10]1[CH:14]=[CH:13][CH2:12][CH2:11]1>N1C=CC=CC=1>[O:10]1[CH2:11][CH2:12][CH2:13][CH:14]1[N:6]1[CH:7]=[C:2]([F:1])[C:3](=[O:9])[N:4]([CH:11]2[CH2:12][CH2:13][CH2:14][O:10]2)[C:5]1=[O:8]

참가 물질

4

반응물 2

HCID 33855-FluorouracilHCID 709342,3-Dihydrofuran

생성물 1

HCID 1249561,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
160 °C

실험 절차

In 20.8 ml of pyridine were dissolved 5.2 g (40 m mol) of 5-fluorouracil and 9.8 g (140 m mol) of 2,3-dihydrofuran. The solution was heated at about 160° C. in a closed tubular reactor under agitation for 5 hours. The resultant reaction mixture was treated similarly to Example 7 to give the above mentioned-compound.

후처리

  1. customThe resultant reaction mixture
  2. additionwas treated similarly to Example 7
  3. customto give the above mentioned-compound

출처 및 근거

ORD 기록
ord-1ea1786e9d7141798e9e1650d0b1a6f5
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04249006

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