Sodium Hydroxide → 2-p-Chlorophenyl-2(2,3-dibromopropionyl)5-methoxymethyl oxazolidine

HRID 1413323노트

반응식

HRID 1413323 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH3:15])[O:9]2)=[CH:4][CH:3]=1.[Br:16][CH:17]([CH2:21][Br:22])[C:18](Cl)=[O:19].[OH-].[Na+]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:18](=[O:19])[CH:17]([Br:16])[CH2:21][Br:22])[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH3:15])[O:9]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 867902,3-Dibromopropanoyl chlorideHCID 20291464p-Chlorophenyl-5-methoxymethyl oxazolidine

생성물 1

HCID 202914622-p-Chlorophenyl-2(2,3-dibromopropionyl)5-methoxymethyl oxazolidine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To 20.8 milliliters of 25 percent w/v, p-chlorophenyl-5-methoxymethyl oxazolidine solution in 50 milliliters of benzene was added 5 grams of 2,3-dibromopropionyl chloride. To this solution was added 1.6 grams of 50% sodium hydroxide. After washing with water, drying and removal of the benzene in vacuo, there was obtained 4.8 grams of the title compound, nD30 1.5478. Analytical data supports the structure.

후처리

  1. washAfter washing with water
  2. customdrying
  3. customremoval of the benzene in vacuo

출처 및 근거

ORD 기록
ord-3fb7dcb038144c808c643805cafe75c7
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04249931

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