Sodium Hydroxide → 2-p-Chlorophenyl-3(3-carbomethoxypropionyl)5-propoxymethyl oxazolidine

HRID 1413324

반응식

HRID 1413324 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH2:15][CH2:16][CH3:17])[O:9]2)=[CH:4][CH:3]=1.[C:18]([CH2:22][CH2:23][C:24](Cl)=[O:25])([O:20][CH3:21])=[O:19].[OH-].[Na+]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[N:12]([C:24](=[O:25])[CH2:23][CH2:22][C:18]([O:20][CH3:21])=[O:19])[CH2:11][CH:10]([CH2:13][O:14][CH2:15][CH2:16][CH3:17])[O:9]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 73888Butanoic acid, 4-chloro-4-oxo-, methyl esterHCID 538735082-p-Chlorophenyl-5-propoxymethyl oxazolidine

생성물 1

HCID 202914672-p-Chlorophenyl-3(3-carbomethoxypropionyl)5-propoxymethyl oxazolidine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To 25.6 milliliters of 25 percent w/v, 2-p-chlorophenyl-5-propoxymethyl oxazolidine solution in 50 milliliters of benzene was added 3.8 grams of 3-carbomethoxypropionyl chloride. To this reaction mixture was added 2 grams of 50% sodium hydroxide. Upon completion of the reaction solvent, benzene, was removed in vacuo. There was obtained 6.0 grams of the title compound, nD30 1.4975. Analytical data supports the structure.

후처리

  1. customUpon completion of the reaction solvent, benzene, was removed in vacuo

출처 및 근거

ORD 기록
ord-62d50b6a99f748c8aeb5a3f311f08068
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04249931

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