Hydrazine hydrate (1:1) → 2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

HRID 1413364노트

반응식

HRID 1413364 반응식
[C:1]1([C:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[NH:11][C:10](=S)[CH2:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:20][NH2:21]>CO>[C:1]1([C:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]=[C:10]([NH:20][NH2:21])[CH2:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 28029055-Phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-thione

생성물 1

HCID 126123892-hydrazino-5-phenyl-3H-1,4-benzodiazepine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A stirred mixture of 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-thione (7.45 g., 0.03 mole) in methanol (300 ml.) was allowed to react with hydrazine hydrate (6.0 g., 0.12 mole) to give 5-phenyl-3H-1,4-benzodiazepin-2-yl hydrazine as an oil. A solution of thio material in tetrahydrofuran (75 ml.) was cooled in an ice bath and treated with a solution of chloroacetyl chloride (3.39 g., 0.03 mole) in tetrahydrofuran (25 ml.) to give 6.43 g. of chloroacetic acid, 2-(5-phenyl-3H-1,4-benzodiazepin-2-yl) hydrazide (A).

출처 및 근거

ORD 기록
ord-aaddeba4606449c8bb9f89290fd224a6
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04250094

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