Phenyl Isothiocyanate → N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

HRID 1413428노트

반응식

HRID 1413428 반응식
C[O-].[Na+].I.[NH:5]=[C:6]1[N:10]([CH3:11])[CH2:9][CH2:8][S:7]1.[C:12]1([N:18]=[C:19]=[S:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(O)C>[CH3:11][N:10]1[CH2:9][CH2:8][S:7][C:6]1=[N:5][C:19]([NH:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[S:20]

참가 물질

5

반응물 3

HCID 7673Phenyl IsothiocyanateHCID 27705073-methyl-1,3-thiazolidin-2-imine HydroiodideHCID 10942334Sodium Methoxide

생성물 1

HCID 54546998N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Sodium methoxide (2.16 g) was added to a mixture of 2-imino-3-methylthiazolidine hydroiodide (10.0 g) in ethanol (50 ml) and brought to reflux, with stirring. Phenylisothiocyanate (5.4 g) in ethanol (20 ml) was added to the mixture over 5 minutes and the resultant mixture heated under reflux, with stirring, for one hour then cooled in ice. Filteration gave analytically pure product, mpt 169°-170°, which may be recrystallised from isopropanol.

후처리

  1. temperatureto reflux
  2. temperatureunder reflux
  3. stirringwith stirring, for one hour
  4. temperaturethen cooled in ice
  5. customFilteration gave analytically pure product, mpt 169°-170°, which
  6. custommay be recrystallised from isopropanol

출처 및 근거

ORD 기록
ord-bbf1b3724acf419abc9d1f16a86dfde4
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04250173

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