Butyric acid, 4-(p-chloro-N-2,6-xylylbenzamido)- → methyl N-[N-(p-chlorobenzoyl)-4-(2,6dimethylanilino)butyryl]-L-alaninate
반응식
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20](O)=[O:21])[C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])=[O:7])=[CH:4][CH:3]=1.[NH2:25][C@H:26]([C:28]([O:30][CH3:31])=[O:29])[CH3:27]>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20]([NH:25][C@H:26]([C:28]([O:30][CH3:31])=[O:29])[CH3:27])=[O:21])[C:9]2[C:10]([CH3:16])=[CH:11][CH:12]=[CH:13][C:14]=2[CH3:15])=[O:7])=[CH:4][CH:3]=1참가 물질
3
실험 절차
Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyric acid and methyl L-alaninate and suitable processing produces methyl N-[N-(p-chlorobenzoyl)-4-(2,6dimethylanilino)butyryl]-L-alaninate (M.P. 91° to 92°), saponification of which and processing of the reaction product yields N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-L-alanine (M.P. 159° to 161°).
출처 및 근거
- ORD 기록
- ord-ee1dc04540464853bfcc9edf947574eb
- 출처 데이터셋
- uspto-grants-1981_02