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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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3-(4-Chlorophenyl)-4-isopropyloxazolidine-2,5-dione → 3-Benzylpyrrolylmethyl 2-(4-chlorophenylamino)-3-methylbutanoate

HRID 1413969
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HRID 1413969 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]([CH:13]([CH3:15])[CH3:14])[C:11](=[O:16])[O:10][C:9]2=O)=[CH:4][CH:3]=1.[CH2:18]([C:25]1[CH:29]=[CH:28][NH:27][C:26]=1CO)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CN(C)C1C=CN=CC=1.O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH:12]([CH:13]([CH3:15])[CH3:14])[C:11]([O:10][CH2:9][C:26]2[NH:27][CH:28]=[CH:29][C:25]=2[CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:16])=[CH:4][CH:3]=1
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참가 물질

5

반응물 2

HCID 132294943-(4-Chlorophenyl)-4-isopropyloxazolidine-2,5-dioneHCID 543430813-Benzyl-1-pyrrolylmethanol

생성물 1

HCID 202893053-Benzylpyrrolylmethyl 2-(4-chlorophenylamino)-3-methylbutanoate

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 3-(4-chlorophenyl)-4-isopropyloxazolidine-2,5-dione (336 mg, 1.32 mmol) and 4-dimethylaminopyridine in 5 ml of dry tetrahydrofuran is added a solution of 3-benzylpyrrolylmethyl alcohol (1.26 mmol) in 3 ml of dry tetrahydrofuran. The reaction mixture is stirred for about 20 hours, under dry air, and then diluted with ether followed by washing with saturated aqueous sodium bicarbonate, water and saturated aqueous sodium chloride. After drying over calcium sulfate, solvent is evaporated. The crude product is chromatographed on a rotary chromatograph eluting with 15% ether/hexane to give 3-benzylpyrrolylmethyl 2-(4-chlorophenylamino)-3-methylbutanoate.

후처리

  1. customunder dry air
  2. additiondiluted with ether
  3. washby washing with saturated aqueous sodium bicarbonate, water and saturated aqueous sodium chloride
  4. dry with materialAfter drying over calcium sulfate, solvent
  5. customis evaporated
  6. customThe crude product is chromatographed on a rotary chromatograph
  7. washeluting with 15% ether/hexane

출처 및 근거

ORD 기록
ord-db062ecfb85846a4b9ba7ce355641982
출처 데이터셋
uspto-grants-1981_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04252724

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