Sodium Hydroxide → 2-(4,5-Diphenyl-1,3-oxazol-2-ylthio)acetic acid

HRID 1414203

반응식

HRID 1414203 반응식
[C:1]1([C:7]2[N:8]=[C:9]([S:18][CH2:19][C:20]([O:22]CC)=[O:21])[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([C:7]2[N:8]=[C:9]([S:18][CH2:19][C:20]([OH:22])=[O:21])[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 776821Ethyl [(4,5-diphenyl-1,3-oxazol-2-yl)thio]acetate

생성물 1

HCID 7224662-(4,5-Diphenyl-1,3-oxazol-2-ylthio)acetic acid수율 80.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

10 g ethyl S-(4,5-diphenyloxazol-2-yl)-mercaptoacetate dissolved in 30 ml ethanol were mixed with 30 ml 40% NaOH and maintained for 1 hour at room temperature. The sodium salt which separated from the reaction mixture was redissolved by means of addition of 200 ml distilled water. The alkaline solution was slowly poured into 300 ml ice-cooled 15% HCl. The precipitated S-(4,5-diphenyloxazol-2-yl)-mercaptoacetic acid was filtered, washed with water and crystallized from aqueous ethanol to give 7.4 g of a product melting at 137°-139° C (yield = 80.7%).

후처리

  1. customThe sodium salt which separated from the reaction mixture
  2. dissolutionwas redissolved by means of addition of 200 ml
  3. distillationdistilled water
  4. additionThe alkaline solution was slowly poured into 300 ml ice-
  5. temperaturecooled 15% HCl
  6. filtrationThe precipitated S-(4,5-diphenyloxazol-2-yl)-mercaptoacetic acid was filtered
  7. washwashed with water
  8. customcrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-45b85c4d28754cbc80645a33f51066ed
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04001228

연결된 노트

불러오는 중…