Water → 3-{[(tert-Butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoic Acid

HRID 14144노트

반응식

HRID 14144 반응식
[C:1]([O:5][C:6]([N:8]([CH2:13][C:14]1[CH:15]=[C:16]([CH:21]=[C:22]([CH3:24])[CH:23]=1)[C:17]([O:19]C)=[O:18])[CH2:9][CH2:10][CH2:11][CH3:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[OH-].[Li+]>CO.O1CCCC1>[C:1]([O:5][C:6]([N:8]([CH2:13][C:14]1[CH:15]=[C:16]([CH:21]=[C:22]([CH3:24])[CH:23]=1)[C:17]([OH:19])=[O:18])[CH2:9][CH2:10][CH2:11][CH3:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

참가 물질

6

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 21086193HCID 21086193, 화합물

생성물 1

HCID 210858673-{[(tert-Butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoic Acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of methyl 3-{[(tert -butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoate (70 mg, 0.21 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (88 mg, 2.1 mmol), and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound.

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutiondissolved in methylene chloride
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e75fcc1cc8834dd5a9f293fa26fd6f2f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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