Acetic Anhydride → HCID 21488089, 화합물

반응식

[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][NH:7][CH3:8])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].C(O[C:20](=[O:22])[CH3:21])(=O)C>>[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][N:7]([CH3:8])[C:20](=[O:22])[CH3:21])[CH2:3][CH2:2]1

참가 물질

반응물 3

HCID 7918Acetic Anhydride

HCID 11430Potassium Carbonate

HCID 214880801-Cyclopropyl-3-(methylamino)propan-1-one

생성물 1

HCID 21488089HCID 21488089, 화합물

실험 절차

A crude solution of 1-cyclopropyl-3-methylamino-1-propanone was cooled to 8°-10° C. and 8.2 g. (0.06 mole) of potassium carbonate was added, followed by 50 g. (0.5 mole) of acetic anhydride. The mixture was stirred until it warmed to room temperature. The benzene layer was separated, dried over magnesium sulfate, concentrated, and the residual oil distilled at 99°-150° C./0.1 mm. The distillate weighed 65 g. It was calculated to contain 80% of 1-cyclopropyl-3-(N-methylacetamido)-1-propanone by the nuclear magnetic resonance spectrum.