홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

3-Chloropropyl(diethyl)amine → 3-p-Toluoyl-2-[4-(3-diethylaminopropoxy)phenyl]benzofuran

HRID 1414604
노트
인쇄 미리보기

반응식

HRID 1414604 반응식
[Na].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:26]=[CH:25][CH:24]=[CH:23][C:12]=3[C:13]=2[C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[CH2:27]([N:29]([CH2:34][CH3:35])[CH2:30][CH2:31][CH2:32]Cl)[CH3:28]>C1(C)C=CC=CC=1.CO>[CH2:27]([N:29]([CH2:34][CH3:35])[CH2:30][CH2:31][CH2:32][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[CH:26]=[CH:25][CH:24]=[CH:23][C:12]=3[C:13]=2[C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[CH:7][CH:8]=1)[CH3:28]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 669183-Chloropropyl(diethyl)amineHCID 5360545SodiumHCID 214879512-p-Hydroxyphenyl-3-p-methylbenzoylbenzofuran

생성물 1

HCID 103677653-p-Toluoyl-2-[4-(3-diethylaminopropoxy)phenyl]benzofuran

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 1140Toluene
용매
2회

실험 절차

To a solution of 0.177 g. (7.7 g.-atom) of sodium dissolved in 25 ml. of dry methanol was added a solution of 2.4 g. (7.3 mmol.) of 2-p-hydroxyphenyl-3-p-methylbenzoylbenzofuran in 75 ml. of toluene and 10 ml. of methanol. The mixture was refluxed for 15 minutes, then the methanol was removed by distillation. A solution of 1.15 g. (7.7 mmol.) of 3-diethylaminopropyl chloride in 25 ml. of toluene was then added and the resulting mixture was refluxed for 6 hours. After cooling, the reaction mixture was filtered and the filtrate was concentrated to give the title compound.

후처리

  1. temperatureThe mixture was refluxed for 15 minutes
  2. customthe methanol was removed by distillation
  3. temperaturethe resulting mixture was refluxed for 6 hours
  4. temperatureAfter cooling
  5. filtrationthe reaction mixture was filtered
  6. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-d08a998f14d34d68b027e1aa84a112db
출처 데이터셋
uspto-grants-1977_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04001426

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트