Epichlorohydrin → HCID 21487960, 화합물

HRID 1414619노트

반응식

HRID 1414619 반응식
[OH-].[Na+].[C:3]([C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[O:13][C:12]=1[C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:27]([CH:29]1[O:31][CH2:30]1)Cl>>[C:3]([C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[O:13][C:12]=1[C:20]1[CH:21]=[CH:22][C:23]([O:26][CH2:27][CH:29]2[O:31][CH2:30]2)=[CH:24][CH:25]=1)(=[O:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 3

HCID 7835EpichlorohydrinHCID 14798Sodium HydroxideHCID 13264989[2-(4-Hydroxyphenyl)-1-benzofuran-3-yl](phenyl)methanone

생성물 1

HCID 21487960HCID 21487960, 화합물

실험 절차

To a mixture of 1.6 g. (0.04 mol.) of sodium hydroxide and 3.7 g. (0.012 mol.) of 3-benzoyl-2-p-hydroxyphenylbenzofuran was added with stirring 10.2 g. (0.11 mol.) of epichlorohydrin. The reaction mixture was refluxed for 1.5 hours, then it was cooled and extracted with methylene chloride. The extract was dried (MgSO4) and concentrated to give a residue which, after chromatography, gave 3-benzoyl-2-[4'-(2,3-epoxypropoxy)phenyl]benzofuran.

후처리

  1. additionTo a mixture of 1.6 g
  2. temperatureThe reaction mixture was refluxed for 1.5 hours
  3. temperatureit was cooled
  4. extractionextracted with methylene chloride
  5. dry with materialThe extract was dried (MgSO4)
  6. concentrationconcentrated
  7. customto give a residue which

출처 및 근거

ORD 기록
ord-bfb76981e72644e185d32e8815f122aa
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04001426

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