p-Toluenesulfonic acid → 6-Acetoxy-2-naphthyl-alpha-methylacetic acid

HRID 1414673노트

반응식

HRID 1414673 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:6]=[CH:5]2.[C:17](OC(=O)C)(=[O:19])[CH3:18].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[C:17]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:6]=[CH:5]2)(=[O:19])[CH3:18]

참가 물질

4

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 7918Acetic AnhydrideHCID 162920Desmethylnaproxen

생성물 1

HCID 203351926-Acetoxy-2-naphthyl-alpha-methylacetic acid

실험 절차

A mixture of 2.2 g. of 6-hydroxy-2-naphthyl-α-methylacetic acid, 50 ml. of acetic anhydride, and 100 mg. of p-toluenesulfonic acid is stirred for four hours at 50° C. The mixture is evaporated, water is added, and the mixture is extracted with diethyl ether which is washed with water to neutrality, dried over sodium sulfate, and evaporated to yield 6-acetoxy-2-naphthyl-α-methylacetic acid.

후처리

  1. additionA mixture of 2.2 g
  2. customThe mixture is evaporated
  3. additionwater is added
  4. extractionthe mixture is extracted with diethyl ether which
  5. washis washed with water to neutrality
  6. dry with materialdried over sodium sulfate
  7. customevaporated

출처 및 근거

ORD 기록
ord-0d28150d4ff0458b8145b35eef5d3070
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04001301

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