2-Propanethiol → N-Acetyl-DL-phenylglycine

HRID 1414855

반응식

HRID 1414855 반응식
[C:1]([NH:4][C:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(SC)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2].C(S)(C)C.C(=O)([O-])[O-].[K+].[K+].CO.O>O>[C:1]([NH:4][CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 63642-PropanethiolHCID 11430Potassium CarbonateHCID 21485357HCID 21485357, 화합물HCID 22242641Methanol--water (1/1)

생성물 1

HCID 85935N-Acetyl-DL-phenylglycine수율 90%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

340 Milligrams of N-acetylamino-α-methylthiophenylacetic acid, 240 mg of isopropyl mercaptan, and 351 mg of potassium carbonate were added to 10 ml of a methanol-water mixture (9:1), and refluxed for 3 hours. Following a reduced pressure concentration of the reaction mixture to approximately 1 ml, 20 ml of water was added to the concentrate, which was then extracted with ethyl acetate. The organic phase was dried with Glauber's salt, and concentrated under reduced pressure. The residue was crystallized from an ether-n-hexane system, to provide 247 mg of α-acetylaminophenylacetic acid. The yield was 90%.

후처리

  1. temperaturerefluxed for 3 hours
  2. additionwas added to the concentrate, which
  3. extractionwas then extracted with ethyl acetate
  4. dry with materialThe organic phase was dried with Glauber's salt
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was crystallized from an ether-n-hexane system

출처 및 근거

ORD 기록
ord-a16b058b1d63453f9222fce9b6bf70df
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04002682

연결된 노트

불러오는 중…