Water → 4-Chloro-5-(1-methylhydrazino)-2-phenyl-3(2H)-pyridazinone

HRID 1414873

반응식

HRID 1414873 반응식
[Cl:1][C:2]1[C:3](=[O:15])[N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1Cl.[CH3:16][NH:17][NH2:18].O>CO>[Cl:1][C:2]1[C:3](=[O:15])[N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1[N:17]([CH3:16])[NH2:18]

참가 물질

5

반응물 3

HCID 962WaterHCID 6061MethylhydrazineHCID 728134,5-Dichloro-2-phenyl-3(2H)-pyridazinone

생성물 1

HCID 3766864-Chloro-5-(1-methylhydrazino)-2-phenyl-3(2H)-pyridazinone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution consisting of 22.9 grams of 4,5-dichloro-2-phenylpyridazin-3(2H)-one in 120 grams of methanol is added 20 grams of methylhydrazine. The reactants are heated to reflux for two hours, cooled and poured into one kilogram of water. The resulting precipitate is separated by filtration, washed with water and dried. The solid is crystallized from benzene and methanol to yield 4-chloro-2-phenyl-5-(1-methylhydrazino)-pyridazine-3(2H)-one (m.p. 128° to 130° C with decomposition).

후처리

  1. temperatureThe reactants are heated
  2. temperatureto reflux for two hours
  3. temperaturecooled
  4. customThe resulting precipitate is separated by filtration
  5. washwashed with water
  6. customdried
  7. customThe solid is crystallized from benzene and methanol

출처 및 근거

ORD 기록
ord-1e39f32ecc734faaa13609b438039ac2
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04002751

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