Acetic Acid → HCID 21485896, 화합물

HRID 1414891노트

반응식

HRID 1414891 반응식
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:18][CH3:19])[CH:8]=2)[N:3]=1.O.[NH2:21][NH2:22].C(O)(=O)C>C(O)C>[NH:21]([C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:18][CH3:19])[CH:8]=2)[N:3]=1)[NH2:22]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 24654Hydrazine hydrate (1:1)HCID 214859182-Chloro-6-methoxy-4-phenylquinazoline

생성물 1

HCID 21485896HCID 21485896, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 9.7 g of 2-chloro-4-phenyl-6-methoxyquinazoline in 300 ml of ethanol were added 15 ml of hydrazine hydrate and 8 ml of glacial acetic acid and the mixture was refluxed for 5 hours. After the precipitate was filtered off, the filtrate was concentrated in vacuo to give crystals. The crystals were collected by filtration, washed with ethanol, and dried to give 7.8 g of 2-hydrazino-4-phenyl-6-methoxyquinazoline, a part of which was recrystallized from ethanol to give yellow scales, m.p. 151° - 152° C.

후처리

  1. temperaturethe mixture was refluxed for 5 hours
  2. filtrationAfter the precipitate was filtered off
  3. concentrationthe filtrate was concentrated in vacuo
  4. customto give crystals
  5. filtrationThe crystals were collected by filtration
  6. washwashed with ethanol
  7. customdried

출처 및 근거

ORD 기록
ord-59bad7b51a1d48c5bf4d06c1f1f26702
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04002755

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