Methanol → HCID 21485772, 화합물

HRID 1414958

반응식

HRID 1414958 반응식
[C:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][CH2:13][C:14](=[O:22])[CH2:15][CH2:16]N(CC)CC)[CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2].C(OC1C=C(CCCC(=O)C=C)C=CC=1)(=O)C.[CH3:40][CH:41]1[C:45](=[O:46])[CH2:44][CH2:43][C:42]1=[O:47].CO>[OH-].[K+].C(Cl)(Cl)Cl>[C:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][CH2:13][C:14](=[O:22])[CH2:15][CH2:16][C:41]2([CH3:40])[C:45](=[O:46])[CH2:44][CH2:43][C:42]2=[O:47])[CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

참가 물질

7

반응물 4

HCID 887MethanolHCID 130052-Methyl-1,3-cyclopentanedioneHCID 214854206-m-Acetoxyphenyl-1-diethylaminohexan-3-oneHCID 214855806-m-Acetoxyphenylhex-1-en-3-one

생성물 1

HCID 21485772HCID 21485772, 화합물

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 14797Potassium Hydroxide용매

실험 절차

Reflux a mixture of 6-(m-acetoxyphenyl)-1-diethylaminohexan-3-one and 6-(m-acetoxyphenyl)hex-1-en-3-one (1 g), with 2-methylcyclopentane-1,3-dione (1.5 g) in 0.12% methanolic potassium hydroxide (6 cc) for 18 hours. Remove methanol (2 cc) under reduced pressure and add chloroform (60 cc). Wash the solution in turn with dilute sulfuric acid (25 cc), saturated potassium bicarbonate solution, and brine; dry and evaporate the solvent. The product (0.8 g) is the adduct 2-(6-m-acetoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione in admixture with some of the corresponding free phenol; infrared absorption: 2.86 to 3.08 (broad low-intensity band), 5.71, 5.81, 5.85, and 8.26 μ.

후처리

  1. temperatureReflux
  2. washWash the solution in turn with dilute sulfuric acid (25 cc), saturated potassium bicarbonate solution, and brine
  3. customdry
  4. customevaporate the solvent
  5. customabsorption

출처 및 근거

ORD 기록
ord-bd5a066270e1404bb3a2ccbce35d50b6
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04002746

연결된 노트

불러오는 중…