Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-Methoxyestra-2,5(10)-dien-17beta-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Estradiol 3-methyl ether | HCID 246206 | — |
| 반응물 | Lithium | HCID 3028194 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Methoxyestra-2,5(10)-dien-17beta-ol | HCID 101963 | 64.2% |
반응 단계
Add dl-3-methoxyestra-1,3,5(10)-trien-17β-ol (1.3 g) in tetrahydrofuran (40 ml) to a stirred solution of lithium (1.3 g) in liquid ammonia (100 ml). After 15 minutes add ethanol (20 ml) dropwise and when the blue color is discharged add ammonium chloride and water and extract the mixture with ether. Wash, dry and evaporate the ethereal solution and recrystallize the residue from ethanol-hexane to obtain dl-3-methoxyestra-2,5(10)-dien-17β-ol (0.84 g), m.p. 120°-123°; infrared absorption maxima at 3.25 μ, 5.8 μ, 6 μ.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04002746 |
| 출처 데이터셋 | uspto-grants-1977_01 |
| ORD ID | ord-af236d2dc2e74c6a90062a74e8f1b137 |
| 출처 메모 | uspto-grants-1977_01 |