反应详情

Add dl-3-methoxyestra-1,3,5(10)-trien-17β-ol (1.3 g) in tetrahydrofuran (40 ml) to a stirred solution of lithium (1.3 g) in liquid ammonia (100 ml). After 15 minutes add ethanol (20 ml) dropwise and when the blue color is discharged add ammonium chloride and water and extract the mixture with ether. Wash, dry and evaporate the ethereal solution and recrystallize the residue from ethanol-hexane to obtain dl-3-methoxyestra-2,5(10)-dien-17β-ol (0.84 g), m.p. 120°-123°; infrared absorption maxima at 3.25 μ, 5.8 μ, 6 μ.

1. extractionextract the mixture with ether
2. washWash
3. customdry
4. customevaporate the ethereal solution
5. customrecrystallize the residue from ethanol-hexane