Acetic Acid → HCID 12491129, 화합물

HRID 1415433노트

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HRID 1415433 반응식
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4](S(O)(=O)=O)=[CH:3][CH:2]=1.[C:12]([OH:15])(=[O:14])[CH3:13].C(OC(=O)C)(=O)C.[CH:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:1]12[CH2:11][CH2:13][C:12](=[O:15])[O:14][C:26]=1[CH2:25][CH2:24][CH2:23][CH2:28][CH2:27][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2

참가 물질

5

반응물 4

HCID 176Acetic AcidHCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 7918Acetic Anhydride

생성물 1

HCID 12491129HCID 12491129, 화합물수율 32.8%

실험 절차

Five parts of the foregoing β-(2-oxocyclododecyl)propionic acid morpholine amide, 0.2 part of paratoluene sulfonic acid, 50 parts of acetic acid, and 5 parts of acetic anhydride were refluxed for 36 hours. And then 300 parts of benzene was added into the solution and washed with aqueous sodium bicarbonate to remove the catalyst and acetic acid. Thereafter, the resulting solution was treated by the same method as described in Example 1 to give 1.54 parts of 13-oxabicyclo(10.4.0)hexadec-1(12)-en-14-one in 32.8% yield.

후처리

  1. washwashed with aqueous sodium bicarbonate
  2. customto remove the catalyst and acetic acid
  3. additionThereafter, the resulting solution was treated by the same method

출처 및 근거

ORD 기록
ord-984e58c06d634459a47bef58b3326a8b
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04005107

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