Hydrogen Bromide → HCID 21482727, 화합물
반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1[NH2:9].[BrH:16].BrBr>O>[NH2:9][C:8]1[C:3]([C:2]([F:1])([F:14])[F:15])=[CH:4][C:5]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][C:7]=1[Br:16]참가 물질
5
실험 절차
A suspension of 0.69 g. (0.029 moles) of 3-trifluoromethyl-4-aminobenzenesulfonamide in 7 ml. of water and 7 ml. of 48% hydrobromic acid is treated dropwise with 0.16 ml. of liquid bromine and stirred for 3 hours at room temperature. The reaction mixture is filtered, the solid material washed with 10% aqueous sodium bicarbonate, water and dried. The dried solid is recrystallized from toluene affording 0.76 g. of 4-amino-3-bromo-5-trifluoromethylbenzenesulfonamide m.p. 248°-252° C.
후처리
- additionA suspension of 0.69 g
- filtrationThe reaction mixture is filtered
- washthe solid material washed with 10% aqueous sodium bicarbonate, water
- customdried
- customThe dried solid is recrystallized from toluene affording 0.76 g
출처 및 근거
- ORD 기록
- ord-7186dc6cb6854dbc90763556e445afb0
- 출처 데이터셋
- uspto-grants-1977_01
- 특허 번호
- US04005199
반응 노트
불러오는 중…