Methylamine → 1-Ethyl-3-methylaminopiperidine

HRID 1415545

반응식

HRID 1415545 반응식
[H][H].[CH2:3]([N:5]1[CH2:10][CH2:9][CH2:8][C:7](=O)[CH2:6]1)[CH3:4].[CH3:12][NH2:13]>[Pt](=O)=O.CO>[CH2:3]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([NH:13][CH3:12])[CH2:6]1)[CH3:4]

참가 물질

6

반응물 3

HCID 6329MethylamineHCID 4334391-Ethylpiperidin-3-one hydrochlorideHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 214828091-Ethyl-3-methylaminopiperidine

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

A suspension of 0.25 g. of platinum dioxide in 20 ml. of methanol was shaken under 30 p.s.i. of hydrogen for one hour. To this activated catalyst was added a solution of 7.9 g. (48 mmoles) of 1-ethyl-3-piperidone and 3.1 g. (100 mmoles) of methylamine in 40 ml. of methnol. This mixture was shaken under about 50 p.s.i. of hydrogen for 1.5 hours, then filtered. The solvent was distilled off the filtrate at atmospheric pressure. The residue was then distilled at reduced pressure to give 1-ethyl-3-methylaminopiperidine, b.p. 88°-90.5° C. at 28 mm.

후처리

  1. additionA suspension of 0.25 g
  2. additionTo this activated catalyst was added a solution of 7.9 g
  3. filtrationfiltered
  4. distillationThe solvent was distilled off the filtrate at atmospheric pressure
  5. distillationThe residue was then distilled at reduced pressure

출처 및 근거

ORD 기록
ord-abf4998b4ba34c66bc8fbc364e15c119
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04005208

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