Trimethylsilyl cyanide → alpha-(3,4-Dimethylphenyl)-alpha-(4-sulfamoylanilino)acetonitrile

반응식

[CH3:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[CH3:20])[CH:5]=[N:6][C:7]1[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][CH:8]=1.C[Si]([C:25]#[N:26])(C)C>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:5]([NH:6][C:7]2[CH:8]=[CH:9][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:11][CH:12]=2)[C:25]#[N:26])[CH:17]=[CH:18][C:19]=1[CH3:20]

참가 물질

반응물 2

HCID 82115Trimethylsilyl cyanide

HCID 21862821N-(3,4-Dimethylbenzylidene)-4-sulfamoylaniline

생성물 1

HCID 21862877alpha-(3,4-Dimethylphenyl)-alpha-(4-sulfamoylanilino)acetonitrile

실험 절차

Following a procedure similar to that described in Example 1(ii), but using N-(3,4-dimethylbenzylidene)-4-sulfamoylaniline [prepared as described in step (i) above] and trimethylsilyl cyanide as starting materials, the title compound was obtained as a slightly yellow powder (yield 91%).

출처 및 근거

ORD 기록: ord-b37d1726e620467d9080b10f00ba6219
출처 데이터셋: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05908858

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