Methacrolein → 2-(3-Chloro-4-methoxyphenyl)-4-methyl-1-(4-sulfamoylphenyl)pyrrole

HRID 1415821노트

반응식

HRID 1415821 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([S:20](=[O:23])(=[O:22])[NH2:21])=[CH:16][CH:15]=2)[C:11]#N)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O=[CH:25][C:26](=C)[CH3:27]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([S:20](=[O:23])(=[O:22])[NH2:21])=[CH:16][CH:15]=3)[CH:25]=[C:26]([CH3:27])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

3

반응물 2

HCID 6562MethacroleinHCID 21862805alpha-(3-Chloro-4-methoxyphenyl)-alpha-(4-sulfamoylanilino)acetonitrile

생성물 1

HCID 218628462-(3-Chloro-4-methoxyphenyl)-4-methyl-1-(4-sulfamoylphenyl)pyrrole

실험 절차

Following a procedure similar to that described in Example 1(iii), but using α-(3-chloro-4-methoxyphenyl)-α-(4-sulfamoylanilino)acetonitrile [prepared as described in step (ii) above] and methacrolein as starting materials, the title compound was obtained as a slightly yellow powder (yield 37%), melting at 160-163° C.

출처 및 근거

ORD 기록
ord-20943bb574fe43318ba29bc9bf16b111
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05908858

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