4-Bromophenol → p-Bromophenyl propionate

HRID 1416174

반응식

HRID 1416174 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:16](Cl)(=[O:19])[CH2:17][CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[C:16]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:19])[CH2:17][CH3:18]

참가 물질

6

반응물 3

HCID 78084-BromophenolHCID 8471TriethylamineHCID 62324Propionyl chloride

생성물 1

HCID 90205p-Bromophenyl propionate

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

4-Bromophenol (259 g) and 4-dimethylaminopyridine (1.5 g) were dissolved in dichloromethane (1000 ml), the solution was cooled in an ice bath and triethylamine (219 ml) was added portionwise such that the reaction temperature was kept below 20° C. Propionyl chloride (137 ml) was then added over 1 hour and the resulting mixture was stirred at room temperature for 2 hours. The mixture was washed with water followed by brine, then dried (anhydrous magnesium sulphate) and the solvent removed under reduced pressure to yield 4-bromophenyl propionate (344 g) as a green oil.

후처리

  1. temperaturethe solution was cooled in an ice bath
  2. customwas kept below 20° C
  3. washThe mixture was washed with water
  4. dry with materialdried (anhydrous magnesium sulphate)
  5. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-e23305ecedd6434f86a9cdf31e6750fb
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05912244

연결된 노트

불러오는 중…