Hydrochloric Acid → 5-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(2-isobutoxy-ethyl) ester

HRID 1416726

반응식

HRID 1416726 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:29])[CH2:9][NH:10][CH:11]([CH3:28])[CH2:12][C:13]2[CH:27]=[CH:26][C:16]3[O:17][C:18]([C:23]([OH:25])=[O:24])([C:20]([OH:22])=[O:21])[O:19][C:15]=3[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:30]([O:34][CH2:35][CH2:36]O)[CH:31]([CH3:33])[CH3:32].Cl>>[CH2:30]([O:34][CH2:35][CH2:36][O:24][C:23]([C:18]1([C:20]([O:22][CH2:36][CH2:35][O:34][CH2:30][CH:31]([CH3:32])[CH3:33])=[O:21])[O:17][C:16]2[CH:26]=[CH:27][C:13]([CH2:12][CH:11]([NH:10][CH2:9][CH:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[OH:29])[CH3:28])=[CH:14][C:15]=2[O:19]1)=[O:25])[CH:31]([CH3:33])[CH3:32]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 521158Ethanol, 2-(2-methylpropoxy)-HCID 42813555-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid

생성물 1

HCID 99607145-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(2-isobutoxy-ethyl) ester

실험 절차

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-isobutoxyethanol according to the procedure of Example 1 as a colorless oil; 1H NMR (300 MHz, CDCl3): δ 0.70-0.95 (m, 12H), 1.10-2.0 (complexm, 11H), 3.09-3.29 (m, 4H), 3.51-3.58 (m, 1H), 3.60-3.72 (m, 4H), 4.31-4.48 (m, 2H), 6.70-7.00 (m, 4H), 7.15-7.50 (m, 4H); MS (ES) m/z (relative intensity): 622 (M+ -HCl, 100).

출처 및 근거

ORD 기록
ord-df53c14ba067446cbcfdcf30f6b01d17
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05914339

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