8-Methyl-7-nitroquinoline → HCID 14115670, 화합물

HRID 1416897노트

반응식

HRID 1416897 반응식
[CH3:1][C:2]1[C:3]([N+:12]([O-])=O)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:12][C:3]1[C:2]([CH3:1])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 2541658-Methyl-7-nitroquinolineHCID 2723923Ammonium formate

생성물 1

HCID 14115670HCID 14115670, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 8-methyl-7-nitroquinoline (1.8 g) in methanol (20 mL) is added palladium-on-carbon (10%, 0.45 g) and ammonium formate (2.77 g). The mixture is stirred at room temperature for 30 minutes, then filtered on Celite, with a methanol wash of the solids. The filtrate is rotary evaporated and the residue partitioned between water and methylene chloride. The organic layer is dried over potassium carbonate, filtered and rotary evaporated to afford 7-amino-8-methylquinoline as a yellow solid.

후처리

  1. filtrationfiltered on Celite, with a methanol
  2. washwash of the solids
  3. customThe filtrate is rotary evaporated
  4. customthe residue partitioned between water and methylene chloride
  5. dry with materialThe organic layer is dried over potassium carbonate
  6. filtrationfiltered
  7. customrotary evaporated

출처 및 근거

ORD 기록
ord-b220c06f3c6042068270816a5513ab96
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05916900

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