Hydrogen Bromide → 3-Phenoxyphenol

HRID 1416949

반응식

HRID 1416949 반응식
[O:1]([C:8]1[CH:9]=[C:10]([O:14]C)[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br>C(O)(=O)C>[O:1]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 742521-Methoxy-3-phenoxybenzene

생성물 1

HCID 128423-Phenoxyphenol

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3-Phenoxyanisole (8.3 g) was added to a mixture of 50 mL of 40% HBr and 100 mL of glacial acetic acid. The resultant mixture was heated under reflux for 48 hours, then cooled and concentrated under reduced pressure. The residue was taken up in EtOAc, washed with water, saturated NaHCO3, and brine. After drying with MgSO4, and concentration under reduced pressure, 3-phenoxyphenol was obtained and used without further purification.

후처리

  1. temperatureunder reflux for 48 hours
  2. temperaturecooled
  3. concentrationconcentrated under reduced pressure
  4. washwashed with water, saturated NaHCO3, and brine
  5. dry with materialAfter drying with MgSO4, and concentration under reduced pressure

출처 및 근거

ORD 기록
ord-f89d7d897c4d4a39a8c7436c257186e9
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05916922

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