N-bromobutanimide → 2-bromo-4-(4-pyridinylmethyl)Benzenamine

HRID 1417245

반응식

HRID 1417245 반응식
[Br:1]N1C(=O)CCC1=O.[N:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]2[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=2)=[CH:11][CH:10]=1>CN(C)C=O.C(OCC)C>[Br:1][C:18]1[CH:17]=[C:16]([CH2:15][C:12]2[CH:13]=[CH:14][N:9]=[CH:10][CH:11]=2)[CH:22]=[CH:21][C:19]=1[NH2:20]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 3071584-[(Pyridin-4-yl)methyl]aniline

생성물 1

HCID 218656452-bromo-4-(4-pyridinylmethyl)Benzenamine

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매2회

실험 절차

A solution of 18.34 g (0.103 mol) of N-bromosuccinimide in 60 ml of dimethylformamide is added dropwise, shielded from light, to a solution of 20 g (0.1084 mol) of 4-(4-pyridylmethyl)aniline in 180 ml of dimethylformamide. After 1 hour, the solvent is evaporated off under reduced pressure and the solid is taken up in 200 ml of dichloromethane. The solution is subsequently washed with 100 ml of water and then with 100 ml of a saturated sodium chloride solution. After customary treatment of the organic phase, an oil is obtained which is taken up in 500 ml of diethyl ether, and the whole is left in a refrigerator for 2 days. After filtration, the expected product is obtained.

후처리

  1. customthe solvent is evaporated off under reduced pressure
  2. washThe solution is subsequently washed with 100 ml of water
  3. customAfter customary treatment of the organic phase, an oil is obtained which
  4. waitthe whole is left in a refrigerator for 2 days
  5. filtrationAfter filtration

출처 및 근거

ORD 기록
ord-b176f1137830430bae59f30d7ccaaa13
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877190

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