Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → (E)-2-[4-[4-(1H-Imidazol-1-yl)phenoxy]-2-buten-1-yl]-1H-isoindole-1,3(2H)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-(p-Hydroxyphenyl)imidazole | HCID 82315 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | 2-((2E)-4-chlorobut-2-en-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione | HCID 5709374 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (E)-2-[4-[4-(1H-Imidazol-1-yl)phenoxy]-2-buten-1-yl]-1H-isoindole-1,3(2H)-dione | HCID 67693623 | — |
반응 단계
A solution of 16.0 g of 4-(1H-imidazol-1-yl)phenol in 250 ml of dimethylformamide, is treated with 4.2 g of 60% NaH. To the suspension of the sodium salt, 23.5 g of (E)-2-[4-chloro-2-buten-1-yl)-1H-isoindole-1,3(2H)-dione is added, and the reaction mixture stirred and heated on the steam bath for 16 hours. The dimethylformamide is removed in vacuo, and the residue stirred with 250 ml of water. The insolubles are collected, washed with water, and dried. Recrystallization from ethanol gives the desired product as a solid, m.p. 170°-171° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05877196 |
| 출처 데이터셋 | uspto-grants-1999_03 |
| ORD ID | ord-7e2c0457e8cc4b2d85de1791618a8f7c |
| 출처 메모 | uspto-grants-1999_03 |