反应详情

A solution of 16.0 g of 4-(1H-imidazol-1-yl)phenol in 250 ml of dimethylformamide, is treated with 4.2 g of 60% NaH. To the suspension of the sodium salt, 23.5 g of (E)-2-[4-chloro-2-buten-1-yl)-1H-isoindole-1,3(2H)-dione is added, and the reaction mixture stirred and heated on the steam bath for 16 hours. The dimethylformamide is removed in vacuo, and the residue stirred with 250 ml of water. The insolubles are collected, washed with water, and dried. Recrystallization from ethanol gives the desired product as a solid, m.p. 170°-171° C.

1. additionis added
2. temperatureheated on the steam bath for 16 hours
3. customThe dimethylformamide is removed in vacuo
4. stirringthe residue stirred with 250 ml of water
5. customThe insolubles are collected
6. washwashed with water
7. customdried
8. customRecrystallization from ethanol