Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formamide → 2-[4-[4-(Pyrimidin-4-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N,N',N''-Methylidynetrisformamide | HCID 78505 | — |
| 반응물 | 2-[4-(4-Acetylphenoxy)butyl]-1H-isoindole-1,3(2H)-dione | HCID 67598087 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-[4-[4-(Pyrimidin-4-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione | HCID 67599506 | — |
반응 단계
A mixture of 10.0 g of 2-[4-(4-acetylphenoxy]-butyl]-1H-isoindole-1,3(2H)-dione (Example 42) 10.0 g of tris(formamido)methane, and 20 ml of formamide are combined and the mixture stirred and heated at 160°-165° C. for 8 hours. After dilution with 100 ml of water, the mixture is rendered basic with 10N NaOH, the precipitate collected, washed with water, and air dried. Recrystallization from ethanol gives the pure compound, m.p. 100°-102° C.; yield, 5.0 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05877196 |
| 출처 데이터셋 | uspto-grants-1999_03 |
| ORD ID | ord-14a0374f1cf0424bb6cd26c83a98c3ef |
| 출처 메모 | uspto-grants-1999_03 |